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KMID : 1103720220830010246
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Journal of the Korean Society of Radiology
2022 Volume.83 No. 1 p.246 ~ p.251
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Breast Cancer after Radiation Therapy in a Patient with Li-Fraumeni Syndrome: A Case Report
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Yoon In-Na
Cha Eun-Suk
Kim Jeoung-Hyun
Lee Jee-Eun
Chung Jin
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Abstract
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Li-Fraumeni syndrome (LFS) is an inherited autosomal-dominant tumor-predisposition disorder caused by germline mutations in the TP53 tumor suppressor gene. Since patients with LFS are likely to develop therapy-related cancers, radiation therapy should be avoided if breast cancer is found in these individuals. Herein, we present a case of secondary breast cancer in an LFS patient after radiation and chemotherapy for the first diagnosed breast sarcoma.
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KEYWORD
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Breast Neoplasms, Li-Fraumeni Syndrome, Sarcoma, Second Primary
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